A new ganoderic acid from Ganoderma lucidum mycelia

被引：22
|
作者：
Wang, Jia-Le [1 ]
Li, Ying-Bo [2 ]
Liu, Ru-Ming [2 ]
Zhong, Jian-Jiang [1 ]
机构：
[1] Shanghai Jiao Tong Univ, Key Lab Microbial Metab, Minist Educ, Sch Life Sci & Biotechnol, Shanghai 200240, Peoples R China
[2] E China Univ Sci & Technol, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China
来源：
JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH | 2010年 / 12卷 / 08期
基金：
中国国家自然科学基金;
关键词：
Ganoderma lucidum; Ganodermataceae; 7-O-ethyl GA-O; ethoxyl; cytotoxicity; TRITERPENOIDS; CYTOTOXICITY;
D O I：
10.1080/10286020.2010.493506
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
A new ganoderic acid (GA), 7-O-ethyl ganoderic acid O (GA-O) (1), together with two known compounds, GA-T (2) and GA-Me (3), was isolated and purified from fermented mycelia of Ganoderma lucidum. The structure of the new triterpenoid was elucidated on the basis of the interpretation of extensive spectroscopic data (HR-MS, IR, UV, 1D and 2D NMR) as 3,15,22-triacetoxy-7-ethoxy-5-lanost-8,24E-dien-26-oic acid. The new compound was found to contain a rare ethoxyl group at C-7. In addition, its cytotoxicity against 95D and HeLa human cancer cell lines was also evaluated.
引用
收藏
页码：727 / 730
页数：4
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