BMP inhibits neurite growth by a mechanism dependent on LIM-kinase

被引：17
|
作者：
Matsuura, Iichiro
Endo, Mitsuharu
Hata, Katsuhiko
Kubo, Takekazu
Yamaguchi, Atsushi
Saeki, Naokatsu
Yamashita, Toshihide
机构：
[1] Chiba Univ, Grad Sch Med, Dept Neurobiol, Chou Ku, Chiba 2608670, Japan
[2] Chiba Univ, Grad Sch Med, Dept Neurol Surg, Chou Ku, Chiba 2608670, Japan
来源：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2007年 / 360卷 / 04期
关键词：
bone morphogenetic proteins; neurite; LIM-kinase; neurons; SPINAL-CORD-INJURY; RHO-KINASE; AXON REGENERATION; PROTEIN-KINASE; PHOSPHORYLATION; RECEPTOR; ACTIVATION; CELLS; IDENTIFICATION; EXPRESSION;
D O I：
10.1016/j.bbrc.2007.06.157
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Bone morphogenetic proteins (BMPs) are multifunctional growth factors that belong to the transforming growth factor-beta superfamily. BMPs regulate several crucial aspects of embryonic development and organogenesis. Here, we demonstrate that BMP-2 inhibits the neurite outgrowth of postnatal cerebellar neurons in vitro. Although receptor-regulated Smad proteins are activated by BMP-2, this signal transduction is not necessary for the inhibitory effect of BMP-2. Interestingly, BMP-2 activates LIM-kinase 1 in the neurons, and the dominant negative form of LIM-kinase I abolishes the effect of BMP-2. Thus, BMP-2 inhibits neurite outgrowth by a LIM-kinase 1-dependent mechanism, and our findings add a new member to the group of neurite growth inhibitors. (c) 2007 Elsevier Inc. All rights reserved.
引用
收藏
页码：868 / 873
页数：6
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