IL6-174G/C polymorphism and fracture risk

Several studies have examined the associations of polymorphism in interleukin-6 (IL6) with fracture risk. However, the results were conflicting. Thus, a meta-analysis was conducted to determine the relationship between IL6-174C/G polymorphism and risk of fracture. Databases including PubMed, EMBASE, Wanfang were searched. Summary odds ratios (ORs) and corresponding 95% confidence intervals (CIs) were estimated using random-effects models. Six studies were included in this meta-analysis. IL6-174C/G polymorphism was associated with a significantly increased risk of fracture (OR=1.32; 95% CI, 1.10-1.58; I-2=11%; Figure 1). In the subgroup analysis according to gender, women (RR=1.26; 95% CI, 1.09-1.46; I-2=0%) was significantly associated with risk of fracture. In the age subgroup analysis, old population (RR=1.27; 95% CI, 1.11-1.48; I-2=0%) showed increased fracture risk. However, young population did show increased risk of fracture (RR=1.95; 95% CI, 0.70-5.47; I-2=51%). Postmenopausal women also showed an increased fracture risks (RR=1.24; 95% CI, 1.08-1.44; I-2=0%). This meta-analysis suggested that IL6-174C/G polymorphism contributed the development of fracture.