Combination Therapies for Precision Oncology: The Ultimate Whack-A-Mole Game

被引：5

作者：

Groisberg, Roman ^{[1
]}

Subbiah, Vivek ^{[2
,3
,4
]}

机构：

[1] Rutgers Canc Inst New Jersey, Dept Melanoma Sarcoma Med Oncol & Phase 1, New Brunswick, NJ USA

[2] Univ Texas MD Anderson Canc Ctr, Dept Invest Canc Therapeut, Div Canc Med, 1515 Holcombe Blvd, Houston, TX 77030 USA

[3] Univ Texas MD Anderson Canc Ctr, Div Pediat, Houston, TX 77030 USA

[4] Univ Texas MD Anderson Canc Ctr, MD Anderson Canc Network, Houston, TX 77030 USA

来源：

CLINICAL CANCER RESEARCH | 2021年 / 27卷 / 10期

关键词：

D O I：

10.1158/1078-0432.CCR-21-0254

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The single-agent activity of MEK inhibitors in MAPK or CDK4/6 inhibitors in cyclin pathway aberrant tumors has been limited. The combination of trametinib and palbociclib demonstrates safety, tolerability, and clinical activity in a histology-independent manner, representing a therapeutic approach for patients harboring co-occurring aberrations.

引用

页码：2672 / 2674

页数：3

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