Combination Therapies for Precision Oncology: The Ultimate Whack-A-Mole Game

被引：5
|
作者：
Groisberg, Roman [1 ]
Subbiah, Vivek [2 ,3 ,4 ]
机构：
[1] Rutgers Canc Inst New Jersey, Dept Melanoma Sarcoma Med Oncol & Phase 1, New Brunswick, NJ USA
[2] Univ Texas MD Anderson Canc Ctr, Dept Invest Canc Therapeut, Div Canc Med, 1515 Holcombe Blvd, Houston, TX 77030 USA
[3] Univ Texas MD Anderson Canc Ctr, Div Pediat, Houston, TX 77030 USA
[4] Univ Texas MD Anderson Canc Ctr, MD Anderson Canc Network, Houston, TX 77030 USA
来源：
CLINICAL CANCER RESEARCH | 2021年 / 27卷 / 10期
关键词：
D O I：
10.1158/1078-0432.CCR-21-0254
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The single-agent activity of MEK inhibitors in MAPK or CDK4/6 inhibitors in cyclin pathway aberrant tumors has been limited. The combination of trametinib and palbociclib demonstrates safety, tolerability, and clinical activity in a histology-independent manner, representing a therapeutic approach for patients harboring co-occurring aberrations.
引用
收藏
页码：2672 / 2674
页数：3
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