Synthesis and biological activities of 1-keto-3-carboxy-6,7-methylenedioxy-1,2,3,4-tetrahydronaphthalene derivatives

被引：0

作者：

Prabhu, PJ ^{[1
]}

Bhise, NB ^{[1
]}

Dave, MA ^{[1
]}

机构：

[1] KJ Somaya Coll Sci & Commerce, Dept Chem, Bombay 400077, Maharashtra, India

来源：

ASIAN JOURNAL OF CHEMISTRY | 2003年 / 15卷 / 02期

关键词：

synthesis; biological activity; 1-keto-3-carboxy-6,7-methylenedioxy-1,2,3,4-tetrahydronaphthalene; derivatives;

D O I：

暂无

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

1-Keto-3-carboxy-6,7-methylenedioxy-1,2,3,4-tetrahydronaphthalene (I) was converted to its ester, 1-keto-3-carbmethoxy-6,7-methylenedioxy-1,2,3,4-tetrahydronaphthalene (II) which was treated with hydrazine hydrate to give 1-keto-3-hydrazocarbonyl-6,7-methylenedioxy-1,2,3,4-tetrahydronaphthalene (III). Compound (III) was condensed with various aromatic aldehydes to give corresponding 3-arylidene hydrazocarbonyl-6,7-methylenedioxy-1,2,3,4-tetrahydronaphthalene (IVa-h). On condensation with various substituted benzoxazones, compound (III) gave quinazoline-4-(3H)-one derivatives (Vi-k). Above condensation reactions were also carried out in a microwave oven at 10% energy. Compound (1) was treated with various benzhydrazides in presence of excess Of POCl3 to yield substituted oxadiazoles (VIa-b).

引用

页码：639 / 644

页数：6

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