Surface Plasmon Resonance-Based SiO2 Kretschmann Configuration Biosensor for the Detection of Blood Glucose

In the present study, we report the first high sensitivity glucose biosensor utilizing localized surface plasmon resonance of SiO2 /gold/silver containing structure. The kretschmann is illuminated by 632 nm laser for exact detection of glucose and sensitivity enhancement. To evaluate the structure FDTD or Finite-difference time-domain Method and PML (Perfectly Matched Layer) boundary conditions are applied. The operation mechanism for detection of blood glucose is the monitoring of its refractive index. The proposed blood glucose sensor indicate that a refractive index detection range of 1-1.4 RIU, with a metal thickness variation of 10 nm-30 nm and a temperature variation of 3 K-300 K. The Surface plasmon resonance-based kretschmann configuration biosensor obtained the highest sensitivity of 1050 nm/RIU with a compact size.