Electrochemical behavior of an anticancer drug 5-fluorouracil at methylene blue modified carbon paste electrode

被引：105
|
作者：
Bukkitgar, Shikandar D. [1 ]
Shetti, Nagaraj P. [1 ]
机构：
[1] Visvesvaraya Technol Univ, Dept Chem, KLE Inst Technol, Belgaum 580030, Karnataka, India
来源：
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS | 2016年 / 65卷
关键词：
5-Fltorouracil; Electrochemical behavior; Reaction mechanism; Methylene blue modified electrode; COMPOSITE POTENTIOMETRIC SENSOR; LOOP DIURETIC FUROSEMIDE; VOLTAMMETRIC DETERMINATION; IMPRINTED POLYMER; GOLD ELECTRODE; ASCORBIC-ACID; IONIC LIQUID; OXIDATION; PERFORMANCE; FILM;
D O I：
10.1016/j.msec.2016.04.045
中图分类号：
TB3 [工程材料学]; R318.08 [生物材料学];
学科分类号：
0805 ; 080501 ; 080502 ;
摘要：
A novel sensor for the determination of 5-fluorouracil was constructed by electrochemical deposition of methylene blue on surface of carbon paste electrode. The electrode surface morphology was studied using Atomic force microscopy and XRD. The electrochemical activity of modified electrode was characterized using cyclic voltammetry and differential pulse method. The developed sensor shows impressive enlargement in sensitivity of 5-fluorouracil determination. The peak currents obtained from differential pulse voltammetry was linear with concentration of 5-fluorouracil in the range 4 x 10(-5)-1 x 10(-7) M and detection limit and quantification limit were calculated to be 2.04 nM and 6.18 nM respectively. Further, the sensor was successfully applied in pharmaceutical and biological fluid sample analysis. (C) 2016 Elsevier B.V. All rights reserved.
引用
收藏
页码：262 / 268
页数：7
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