Progression from myelodysplastic syndrome with monosomy 7 to acute monoblastic leukemia with MLL gene rearrangement

被引：0

作者：

Kitazawa, J ^{[1
]}

Umenai, T ^{[1
]}

Ito, E ^{[1
]}

Arai, K ^{[1
]}

Otomo, H ^{[1
]}

Toki, T ^{[1
]}

Seto, M ^{[1
]}

Ueda, R ^{[1
]}

Yokoyama, M ^{[1
]}

机构：

[1] Hirosaki Univ, Sch Med, Dept Pediat, Hirosaki, Aomori 036, Japan

来源：

INTERNATIONAL JOURNAL OF HEMATOLOGY | 1998年 / 67卷 / 01期

关键词：

monosomy; 7; MLL gene rearrangement; t(9; 11)(q22; q23); childhood MDS; leukemic transformation;

D O I：

暂无

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We report a case of myelodysplastic syndrome (MDS) with the 11q23 translocation at its leukemic transformation. Southern blot analysis demonstrated that the MLL gene on chromosome 11 was rearranged during the progression from MDS to acute leukemia. The clinical observation in this case supports the notion that leukemic transformation involves multiple cytogenetic evolutionary progresses, and that MLL gene rearrangement corresponds to the final step of leukemogenesis. (C) 1998 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：23 / 26

页数：4

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