Progression from myelodysplastic syndrome with monosomy 7 to acute monoblastic leukemia with MLL gene rearrangement

被引：0

作者：

Kitazawa, J ^{[1
]}

Umenai, T ^{[1
]}

Ito, E ^{[1
]}

Arai, K ^{[1
]}

Otomo, H ^{[1
]}

Toki, T ^{[1
]}

Seto, M ^{[1
]}

Ueda, R ^{[1
]}

Yokoyama, M ^{[1
]}

机构：

[1] Hirosaki Univ, Sch Med, Dept Pediat, Hirosaki, Aomori 036, Japan

来源：

INTERNATIONAL JOURNAL OF HEMATOLOGY | 1998年 / 67卷 / 01期

关键词：

monosomy; 7; MLL gene rearrangement; t(9; 11)(q22; q23); childhood MDS; leukemic transformation;

D O I：

暂无

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We report a case of myelodysplastic syndrome (MDS) with the 11q23 translocation at its leukemic transformation. Southern blot analysis demonstrated that the MLL gene on chromosome 11 was rearranged during the progression from MDS to acute leukemia. The clinical observation in this case supports the notion that leukemic transformation involves multiple cytogenetic evolutionary progresses, and that MLL gene rearrangement corresponds to the final step of leukemogenesis. (C) 1998 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：23 / 26

页数：4

共 50 条

[1] Infantile Acute Monoblastic Leukemia with MLL Gene Rearrangements
Ritesh Sachdev
Naveen Agarwal
Mohd Ateek Khan
Anil Kumar
[J]. Indian Journal of Hematology and Blood Transfusion, 2015, 31 : 146 - 147
[2] Infantile Acute Monoblastic Leukemia with MLL Gene Rearrangements
Sachdev, Ritesh
Agarwal, Naveen
Khan, Mohd Ateek
Kumar, Anil
[J]. INDIAN JOURNAL OF HEMATOLOGY AND BLOOD TRANSFUSION, 2015, 31 (01) : 146 - 147
[3] Myelodysplastic syndrome, juvenile myelomonocytic leukemia, and acute myeloid leukemia associated with complete or partial monosomy 7
H Hasle
M Aricò
G Basso
A Biondi
A Cantù Rajnoldi
U Creutzig
S Fenu
C Fonatsch
OA Haas
J Harbott
G Kardos
G Kerndrup
G Mann
CM Niemeyer
H Ptoszkova
J Ritter
R Slater
J Starý
B Stollmann-Gibbels
AM Testi
ER van Wering
M Zimmermann
[J]. Leukemia, 1999, 13 : 376 - 385
[4] Myelodysplastic syndrome, juvenile myelomonocytic leukemia, and acute myeloid leukemia associated with complete or partial monosomy 7
Hasle, H
Aricò, M
Basso, G
Biondi, A
Rajnoldi, AC
Creutzig, U
Fenu, S
Fonatsch, C
Haas, OA
Harbott, J
Kardos, G
Kerndrup, G
Mann, G
Niemeyer, CM
Ptoszkova, H
Ritter, J
Slater, R
Stary, J
Stollmann-Gibbels, B
Testi, AM
van Wering, ER
Zimmermann, M
[J]. LEUKEMIA, 1999, 13 (03) : 376 - 385
[5] Erythropoietin-dependent transformation of myelodysplastic syndrome to acute monoblastic leukemia
Bunworasate, U
Arnouk, H
Minderman, H
O'Loughlin, KL
Sait, SNJ
Barcos, M
Stewart, CC
Baer, MR
[J]. BLOOD, 2001, 98 (12) : 3492 - 3494
[6] MONOCYTIC INVOLVEMENT BY MONOSOMY-7 PRECEDED ACUTE MYELOMONOCYTIC LEUKEMIA IN A PATIENT WITH MYELODYSPLASTIC SYNDROME
KERE, J
KNUUTILA, S
RUUTU, T
LESKINEN, R
DELACHAPELLE, A
[J]. LEUKEMIA, 1988, 2 (02) : 69 - 73
[7] Acute Myeloid Leukemia and Myelodysplastic Syndrome with MYC Rearrangement
Wang, Xiaoqiong
Tang, Guilin
Hu, Zhihong
Wang, Wei
Toruner, Gokce
Tang, Zhenya
Bueso-Ramos, Carlos
Medeiros, L. Jeffrey
Hu, Shimin
[J]. LABORATORY INVESTIGATION, 2021, 101 (SUPPL 1) : 903 - 904
[8] Acute Myeloid Leukemia and Myelodysplastic Syndrome with MYC Rearrangement
Wang, Xiaoqiong
Tang, Guilin
Hu, Zhihong
Wang, Wei
Toruner, Gokce
Tang, Zhenya
Bueso-Ramos, Carlos
Medeiros, L. Jeffrey
Hu, Shimin
[J]. MODERN PATHOLOGY, 2021, 34 (SUPPL 2) : 903 - 904
[9] Hidden monosomy 7 in acute myeloid leukemia and myelodysplastic syndrome detected by interphase fluorescence in situ hybridization
Arif, T
Tanaka, K
Damodaran, C
Asou, H
Kyo, T
Dohy, H
Kamada, N
[J]. LEUKEMIA RESEARCH, 1996, 20 (09) : 709 - 716
[10] DETECTION OF MONOSOMY-7 BY FLUORESCENCE IN-SITU HYBRIDIZATION IN ACUTE NONLYMPHOCYTIC LEUKEMIA AND MYELODYSPLASTIC SYNDROME
NAKAGAWA, H
[J]. JAPANESE JOURNAL OF HUMAN GENETICS, 1993, 38 (03): : 257 - 266

← 1 2 3 4 5 →