机构:
Sorbonne Paris Cite, Univ Paris Diderot, Hop Univ Robert Debre, AP HP,Dept Pediat Nephrol, Paris, FranceUniv Nantes, INSERM, Ctr Rech Transplantat & Immunol, Dept Nephrol,UMR 1064, Nantes, France
The dissection of the pathogenic mechanisms of the various forms of the hemolytic uremic syndrome (HUS) has paved the way for the design of specific efficacious treatments. Such mechanistic approach led to a revolution in the management of atypical HUS with the use of the first-in class C5 blocker, eculizumab. The availability of this anticomplement drug has also raised unsettled questions regarding the cost or burden and optimal duration of therapy and its use in secondary HUS. The efficacy of eculizumab in Shiga toxin producing Escherichia coli-associated HUS is not to date established and the results of ongoing prospective studies are eagerly awaited. Nevertheless, the emergence of anticomplement therapies (eculizumab and other drugs in development) has transformed our approach of HUS. (C) 2018 Elsevier Inc. All rights reserved.
机构:
Division of Nephrology and Endocrinology, University of Tokyo Hospital, 7-3-1 Hongo, Bunkyo-ku TokyoDivision of Nephrology and Endocrinology, University of Tokyo Hospital, 7-3-1 Hongo, Bunkyo-ku Tokyo
机构:
Mt Sinai Hosp, Samuel Lunenfeld Res Inst, Toronto, ON M5G 1X5, CanadaMt Sinai Hosp, Samuel Lunenfeld Res Inst, Toronto, ON M5G 1X5, Canada
Heinen, Stefan
Pluthero, Fred G.
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机构:
Hosp Sick Children, Res Inst, Cell Biol Program, Toronto, ON M5G 1X8, CanadaMt Sinai Hosp, Samuel Lunenfeld Res Inst, Toronto, ON M5G 1X5, Canada
Pluthero, Fred G.
van Eimeren, Viola F.
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Hosp Sick Children, Res Inst, Cell Biol Program, Toronto, ON M5G 1X8, Canada
Hosp Sick Children, Div Hematol & Oncol, Toronto, ON M5G 1X8, CanadaMt Sinai Hosp, Samuel Lunenfeld Res Inst, Toronto, ON M5G 1X5, Canada
van Eimeren, Viola F.
Quaggin, Susan E.
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机构:
Mt Sinai Hosp, Samuel Lunenfeld Res Inst, Toronto, ON M5G 1X5, Canada
Univ Toronto, Toronto, ON M5G 1X8, CanadaMt Sinai Hosp, Samuel Lunenfeld Res Inst, Toronto, ON M5G 1X5, Canada
Quaggin, Susan E.
Licht, Christoph
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Hosp Sick Children, Res Inst, Cell Biol Program, Toronto, ON M5G 1X8, Canada
Univ Toronto, Toronto, ON M5G 1X8, Canada
Hosp Sick Children, Div Nephrol, Toronto, ON M5G 1X8, CanadaMt Sinai Hosp, Samuel Lunenfeld Res Inst, Toronto, ON M5G 1X5, Canada