Creutzfeldt-Jakob disease in a patient treated by etanercept for rheumatoid arthritis (RA): Just a coincidence?

被引：4

作者：

Soubrier, Martin ^{[1
]}

Haik, Stephane ^{[2
,3
]}

Hauw, Jean-Jacques ^{[3
]}

Corvol, Jean Christophe

Lyon-Caen, Olivier

Dougados, Maxime ^{[4
]}

机构：

[1] Hop G Montpied, Serv Rhumatol, F-63003 Clermont Ferrand, France

[2] INSERM, Equipe Avenir Malad Prions Chez Homme, Paris, France

[3] Grp Hosp Pitie Salpetriere, AP HP, Lab Neuropathol Raymond Escourolle, F-75634 Paris, France

[4] Univ Paris 05, Hop Cochin, AP HP, Serv Rhumatol B, F-75679 Paris, France

来源：

JOINT BONE SPINE | 2010年 / 77卷 / 02期

关键词：

Rheumatoid arthritis; Biologics; TNF-blocker; Creutzfeldt-Jacob disease; CYTOKINES;

D O I：

10.1016/j.jbspin.2009.05.016

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We describe a patient in whom sporadic Creutzfeldt-Jakob disease (sCJD) occured one year after the onset of etanercept therapy for rheumatoid arthritis (RA). This association could be a chance occurrence. However, TNF-alpha has been implicated in the pathogenesis of neurodegeneration in sCJD and etanercept might worsen the disease. Such an aggravation has been observed in multiple sclerosis, in which TNF-alpha is the key mediator of demyelination. It may be of interest studying the impact of treatment with TNF-alpha antagonists on prevalence and incidence of those neurodegenerative diseases involving TNF-alpha mediation, such as Alzheimer disease. (C) 2009 Societe francaise de rhumatologie. Published by Elsevier Masson SAS. All rights reserved.,

引用

页码：174 / 175

页数：2

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