Inhibitory compound of tyrosinase activity from the sprout of Polygonum hydropiper L. (Benitade)

被引:47
|
作者
Miyazawa, Masuo [1 ]
Tamura, Naotaka [1 ]
机构
[1] Kinki Univ, Fac Sci, Dept Appl Chem, Higashiosaka, Osaka 5778502, Japan
关键词
benitade; tyrosinase activity; (2R; 3R)-(+)-taxifolin;
D O I
10.1248/bpb.30.595
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
A tyrosinase inhibitor was isolated from the sprout of Polygonum hydropiper L. (Benitade) by activity-guided fractionation and identified as (2R,3R)-(+)-taxifolin (1) by spectroscopic means. Compound 1 inhibited 70% of tyrosinase activity at a concentration of 0.50 mm. 1D(50) (50% inhibition dose) value of compound I was 0.24 mm. As compared with tyrosinase inhibitor known cosmetic agent such as arbutin and kojic acid, compound 1 was more inhibited than the former and showed inhibitory effect equal to that of the latter. To study the inhibitory effect of (2R,3R)-(+)-taxifolin derivatives against tyrosinase activity, 3,7,3',4'-taxifolin tetraacetate (2) and 5,7,3',4'-taxifolin teramethyl ether (3) were also assayed together with compound 1.
引用
收藏
页码:595 / 597
页数:3
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