The impact of Primary Ciliary Dyskinesia on the upper respiratory tract

被引：22

作者：

Morgan, Lucy C. ^{[1
,2
,3
]}

Birman, Catherine S. ^{[1
,3
,4
]}

机构：

[1] Univ Sydney, Sydney Med Sch, Sydney, NSW 2006, Australia

[2] Concord Hosp, Dept Thorac Med, Sydney, NSW, Australia

[3] Macquarie Univ, Australian Sch Adv Med, Sydney, NSW 2109, Australia

[4] Childrens Hosp Westmead, Dept ENT Surg, Sydney, NSW, Australia

来源：

PAEDIATRIC RESPIRATORY REVIEWS | 2016年 / 18卷

关键词：

Primary ciliary dyskinesia; Chronic rhinosinusitis; Chronic otitis media with effusion; NASAL NITRIC-OXIDE; CHRONIC RHINOSINUSITIS; OTITIS-MEDIA; LONG-TERM; MACROLIDE THERAPY; TOPICAL THERAPY; CHILDREN; MANAGEMENT; DIAGNOSIS; MANIFESTATIONS;

D O I：

10.1016/j.prrv.2015.09.006

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Primary Ciliary Dyskinesia (PCD) is an autosomal recessive genetic condition affecting the function of motile cilia. The upper respiratory tract is lined with ciliated epithelium and hence a hallmark of PCD is the development, from the neonatal period onwards, of persisting secretion retention and suppurative infection in the middle ear, nose and facial sinuses [1]. This review aims to remind the clinician involved in the care of a patient with PCD of the complexities of making the diagnosis of chronic rhinosinusitis (CRS) and chronic otitis media with effusion (ChOME), the morbidity associated with CRS and ChOME and of current evidence of best practice for the management of these conditions. Crown Copyright (C) 2015 Published by Elsevier Ltd. All rights reserved.

引用

页码：33 / 38

页数：6

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