Synthesis, characterization and antimicrobial activity of copper and zinc-doped hydroxyapatite nanopowders

被引：438

作者：

Stanic, Vojislav ^{[1
]}

Dimitrijevic, Suzana ^{[2
]}

Antic-Stankovic, Jelena ^{[3
]}

Mitric, Miodrag ^{[1
]}

Jokic, Bojan ^{[2
]}

Plecas, Ilija B. ^{[1
]}

Raicevic, Slavica ^{[1
]}

机构：

[1] Univ Belgrade, Vinca Inst Nucl Sci, Belgrade 11001, Serbia

[2] Univ Belgrade, Fac Technol & Met, Belgrade 11001, Serbia

[3] Univ Belgrade, Fac Pharm, Belgrade 11001, Serbia

来源：

APPLIED SURFACE SCIENCE | 2010年 / 256卷 / 20期

关键词：

Hydroxyapatite; Cu; Zn; Nanoparticle; Antimicrobial; CALCIUM PHOSPHATES; ANTIBACTERIAL; HYDROXYLAPATITE; TEMPERATURE; INHIBITION; CADMIUM; IONS;

D O I：

10.1016/j.apsusc.2010.03.124

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Antimicrobial materials based on hydroxyapatite are potentially attractive in a wide variety of medical applications. The synthesis of copper and zinc-doped hydroxyapatite was done by neutralization method. This method consists of dissolving CuO or ZnO in solution of H3PO4, and the slow addition to suspension of Ca(OH)(2) for obtaining monophasic product. Characterization studies from XRD, SEM, TEM and FTIR spectra showed that particles of all samples are of nano size and they do not contain any discernible crystalline impurity. The quantitative elemental analysis showed that the copper and zinc ions fully incorporated into the hydroxyapatite. The antimicrobial effects of doped hydroxyapatite powders against pathogen bacterial strains Escherichia coli, Staphylococcus aureus and pathogen yeast Candida albicans were tested in solid and liquid media. Quantitative test in liquid media clearly showed that copper and zinc-doped samples had viable cells reduction ability for all tested strains. (C) 2010 Elsevier B. V. All rights reserved.

引用

页码：6083 / 6089

页数：7

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