Cytokine storm and use of anakinra in a patient with COVID-19

被引：16
|
作者：
Nemchand, Priyanka [1 ]
Tahir, Hassan [2 ]
Mediwake, Rapti [3 ]
Lee, Jeffrey [1 ]
机构：
[1] Barnet Hosp, Royal Free London NHS Fdn Trust, Rheumatol & Gen Med, Barnet, North Ireland
[2] Barnet Hosp, Rheumatol & Gen Med, London, England
[3] Barnet Hosp, Royal Free London NHS Fdn Trust, Rheumatol, Barnet, North Ireland
来源：
BMJ CASE REPORTS | 2020年 / 13卷 / 09期
关键词：
infections; immunological products and vaccines; musculoskeletal and joint disorders; immunology; infectious diseases; INTERLEUKIN-1;
D O I：
10.1136/bcr-2020-237525
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
We present a case of a 50-year-old man with COVID-19 infection and acute respiratory distress syndrome as a result of a cytokine storm and use of anakinra, an interleukin 1-receptor antagonist that is normally used in the treatment of autoinflammatory disorders in adult patients. We saw a reduction in oxygen requirement and improvements in inflammatory markers and ferritin. Although we cannot determine its clinical efficacy from one case study, it may have a positive effect on the proinflammatory state that is associated with cytokine storm in COVID-19 infection.
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页数：3
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