Catalyst-Free and One-Pot Procedure for Fast Formation of α-Ketoamides Using α-Oxocarboxylic Acids and Amines at Room Temperature

被引：8
|
作者：
Liu, Fuyan [1 ,2 ]
Liu, Yaxu [1 ,2 ]
Chen, Yiping [1 ,2 ]
Sun, Zhongliang [1 ,2 ]
Wang, Bo [1 ,2 ]
机构：
[1] Hainan Univ, Minist Educ, Key Lab Adv Mat Trop Isl Resources, 58 Renmin AVE, Haikou 570228, Peoples R China
[2] Hainan Univ, State Key Lab Marine Resource Utilisat South Chin, 58 Renmin AVE, Haikou 570228, Peoples R China
来源：
CHEMISTRYSELECT | 2017年 / 2卷 / 17期
基金：
美国国家科学基金会;
关键词：
catalyst-free; alpha-ketoamide; one-pot; OXIDATIVE AMIDATION; METHYL KETONES; TERTIARY ENAMIDES; TERMINAL ALKENES; HIGHLY EFFICIENT; DERIVATIVES; AMIDES; ETHYLARENES; GENERATION; AMINATION;
D O I：
10.1002/slct.201700923
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A highly efficient, one-pot, and catalyst-free approach for fast synthesis of an array of alpha-ketoamides starting from easily obtainable alpha-oxocarboxylic acids and primary-/secondary-amines has been developed via insitu activation of acids using stoichiometric 2,4,6-trichloro-1,3,5-trizaine at room temperature, reactions could proceed smoothly to provide the corresponding alpha-ketoamides in good to excellent yields of up to 99%.
引用
收藏
页码：4638 / 4641
页数：4
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