A cyanine-derivative photosensitizer with enhanced photostability for mitochondria-targeted photodynamic therapy

被引：42
|
作者：
Zhao, Xuan [1 ]
Yang, Yanjun [2 ,3 ,4 ]
Yu, Yan [3 ,4 ]
Guo, Siming [1 ]
Wang, Wenxing [3 ,4 ]
Zhu, Sumin [1 ]
机构：
[1] Xuzhou Med Univ, Digest Med Ctr, Affiliated Hosp 2, Xuzhou 221000, Jiangsu, Peoples R China
[2] Shandong Normal Univ, Coll Chem, Jinan 250014, Shandong, Peoples R China
[3] Fudan Univ, Dept Light Sources & Illuminating Engn, Shanghai 200433, Peoples R China
[4] Fudan Univ, Lab Adv Mat, Shanghai 200433, Peoples R China
来源：
CHEMICAL COMMUNICATIONS | 2019年 / 55卷 / 90期
基金：
中国博士后科学基金; 中国国家自然科学基金;
关键词：
NANOPARTICLES; COMBINATION; DELIVERY; CANCER;
D O I：
10.1039/c9cc06157f
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A cyanine-derivative photosensitizer, CYBF2, was synthesized for photodynamic therapy of cancer. The photosensitizer can be activated by red-light with enhanced photostability compared to traditional cyanine photosensitizers. CYBF2 was able to generate singlet oxygen inside the cell mitochondria, which efficiently resulted in apoptosis of cancer cells.
引用
收藏
页码：13542 / 13545
页数：4
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