A Mitochondria-Targeted Photosensitizer Showing Improved Photodynamic Therapy Effects Under Hypoxia

被引：434
|
作者：
Lv, Wen [1 ,2 ]
Zhang, Zhang [1 ,2 ]
Zhang, Kenneth Yin [1 ,2 ]
Yang, Huiran [1 ,2 ]
Liu, Shujuan [1 ,2 ]
Xu, Aqiang [1 ,2 ]
Guo, Song [1 ,2 ]
Zhao, Qiang [1 ,2 ]
Huang, Wei [1 ,2 ,3 ,4 ]
机构：
[1] NUPT, Jiangsu Natl Synerget Innovat Ctr Adv Mat SICAM, Key Lab Organ Elect & Informat Displays, Nanjing 210023, Jiangsu, Peoples R China
[2] NUPT, Jiangsu Natl Synerget Innovat Ctr Adv Mat SICAM, Inst Adv Mat, Nanjing 210023, Jiangsu, Peoples R China
[3] Nanjing Tech Univ NanjingTech, Jiangsu Natl Synerget Innovat Ctr Adv Mat SICAM, Key Lab Flexible Elect KLOFE, Nanjing 211816, Jiangsu, Peoples R China
[4] Nanjing Tech Univ NanjingTech, Jiangsu Natl Synerget Innovat Ctr Adv Mat SICAM, Inst Adv Mat, Nanjing 211816, Jiangsu, Peoples R China
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2016年 / 55卷 / 34期
基金：
中国国家自然科学基金;
关键词：
cell death; hypoxia; iridium; photodynamic therapy; singlet oxygen; PHOTOINDUCED CELL-DEATH; CANCER-THERAPY; PHOTOCHEMICAL PROPERTIES; POLYPYRIDYL COMPLEXES; IRIDIUM(III) COMPLEX; EXCITED-STATES; NANOPARTICLES; LIGAND; TRAFFICKING; INHIBITION;
D O I：
10.1002/anie.201604130
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Organelle-targeted photosensitizers have been reported to be effective photodynamic therapy (PDT) agents. In this work, we designed and synthesized two iridium(III) complexes that specifically stain the mitochondria and lysosomes of living cells, respectively. Both complexes exhibited long-lived phosphorescence, which is sensitive to oxygen quenching. The photocytotoxicity of the complexes was evaluated under normoxic and hypoxic conditions. The results showed that HeLa cells treated with the mitochondria-targeted complex maintained a slower respiration rate, leading to a higher intracellular oxygen level under hypoxia. As a result, this complex exhibited an improved PDT effect compared to the lysosome-targeted complex, especially under hypoxia conditions, suggestive of a higher practicable potential of mitochondria-targeted PDT agents in cancer therapy.
引用
收藏
页码：9947 / 9951
页数：5
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