Catalyst-Free [3+2] Cycloaddition of Unactivated Imines with Cyclopropenones

被引：20
|
作者：
Liu, Si-Wei [1 ,2 ]
Yuan, Chang [1 ]
Jiang, Xue-Fei [1 ]
Wang, Xian-Xun [2 ]
Cui, Hai-Lei [1 ]
机构：
[1] Chongqing Univ Arts & Sci, Lab Asymmetr Synth, 319 Honghe Ave, Chongqing 402160, Peoples R China
[2] Tonichem Pharmaceut Technol Co Ltd, Huizhou 516008, Peoples R China
来源：
ASIAN JOURNAL OF ORGANIC CHEMISTRY | 2020年 / 9卷 / 01期
基金：
中国国家自然科学基金;
关键词：
Catalyst-free; Indolizinoindole; Cyclopropenone; Cycloaddition; Heterocyle; BETA-CARBOLINE; INDOLE ALKALOIDS; TRANSFER HYDROGENATION; SCAFFOLD DIVERSITY; CYCLIZATION; DIPHENYLCYCLOPROPENONE; HETEROCYCLES; AZOMETHINES; ANNULATION; CASCADE;
D O I：
10.1002/ajoc.201900630
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
We have developed a convenient and mild catalyst-free synthesis of structurally diversified indolizinoindoles through [3+2] cycloaddition of dihydro-beta-carbolines and diarylcyclopropenones. Dimethoxydihydroisoquinolines and 3,4-dihydrobenzonaphthyridine can also be used in this process affording corresponding polycyclic N-heterocycles with high molecular complexity.
引用
收藏
页码：82 / 85
页数：4
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