Effects of the 5-HT4 receptor agonist, tegaserod, on in vitro human platelet aggregation

被引:0
|
作者
Serebruany, V. L. [1 ]
El Mouelhi, M. [2 ]
Pfannkuche, H. [3 ]
Rose, K. [4 ]
Marro, M. [5 ]
Angiolillo, D. J. [6 ]
机构
[1] HeartDrug Res Labs, Cardiol, Baltimore, MD USA
[2] Novartis Inst Biomed Res, Translat Med GI, E Hanover, NJ USA
[3] Novartis Pharma AG, Translat Med, Basel, Switzerland
[4] Novartis, Biomarker Dev, E Hanover, NJ USA
[5] Novartis, Translat Med, Horsham, W Sussex, England
[6] Univ Florida, Coll Med, Cardiol, Jacksonville, FL USA
关键词
D O I
暂无
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
PP-WE-022
引用
收藏
页码:631 / 631
页数:1
相关论文
共 50 条
  • [21] The 5-HT4 receptor partial agonist, tegaserod, inhibits the colorectal distension-induced response of rat inferior splanchnic afferents in vitro
    Wei, JY
    Wang, YH
    Mayer, E
    GASTROENTEROLOGY, 2002, 122 (04) : A317 - A318
  • [22] Td-5108, a selective, high intrinsic activity 5-HT4 receptor agonist -: In vitro profile at human recombinant 5-HT4 receptor splice variant and human isolated colon
    Smith, Jacqueline
    Beattie, David T.
    Cuthbert, Alan W.
    Ropenga, Anna
    Marquess, Daniel
    Shaw, Jeng-Peng
    Vickery, Ross
    Humphrey, Patrick P.
    GASTROENTEROLOGY, 2007, 132 (04) : A687 - A687
  • [23] Antinociceptive properties of HTF 919 (tegaserod), a 5-HT4 receptor partial agonist, on colorectal distension in rats.
    Coelho, AM
    Rovira, P
    Fioramonti, J
    Bueno, L
    GASTROENTEROLOGY, 2000, 118 (04) : A835 - A835
  • [24] Tegaserod, a 5-HT4 receptor partial agonist, accelerates gastric emptying and gastrointestinal transit in healthy male subjects
    Degen, L
    Matzinger, D
    Merz, M
    Appel-Dingemanse, S
    Osborne, S
    Lüchinger, S
    Bertold, R
    Maecke, H
    Beglinger, C
    ALIMENTARY PHARMACOLOGY & THERAPEUTICS, 2001, 15 (11) : 1745 - 1751
  • [25] Tegaserod Stimulates 5-HT4 Serotonin Receptors in the Isolated Human Atrium
    Hesse, Christin
    Neumann, Joachim
    Compan, Valerie
    Ponimaskin, Evgeni
    Mueller, Franziska E.
    Hofmann, Britt
    Gergs, Ulrich
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2024, 25 (20)
  • [26] Tegaserod -: A 5-HT4 agonist for women with constipation-predominant irritable bowel syndrome
    Zimmermann, AE
    FORMULARY, 2002, 37 (09) : 449 - +
  • [27] Desensitization of the peristaltic reflex induced by mucosal stimulation with the selective 5-HT4 agonist tegaserod
    Grider, JR
    AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 2006, 290 (02): : G319 - G327
  • [28] A selective 5-HT4 receptor antagonist blocks the effect of tegaserod on rat inferior splanchnic afferents in vitro
    Wang, YH
    Wei, JY
    Mayer, EA
    GASTROENTEROLOGY, 2003, 124 (04) : A569 - A569
  • [29] 5-HT4 Receptor Agonist Effects on Functional Connectivity in the Human Brain: Implications for Procognitive Action
    de Cates, Angharad N.
    Martens, Marieke A. G.
    Wright, Lucy C.
    Gibson, Daisy
    Spitz, Gershon
    van Praag, Cassandra D. Gould
    Suri, Sana
    Cowen, Philip J.
    Murphy, Susannah E.
    Harmer, Catherine J.
    BIOLOGICAL PSYCHIATRY-COGNITIVE NEUROSCIENCE AND NEUROIMAGING, 2023, 8 (11) : 1124 - 1134
  • [30] Tegaserod, a 5HT4 receptor partial agonist, devoid of significant electrocardiographic effects
    Rueegg, PC
    Baldauf, CD
    Dingemanse, SA
    Lefkowitz, M
    Morganroth, J
    GASTROENTEROLOGY, 2001, 120 (05) : A643 - A643