Topical betamethasone/fusidic acid in eczema:: efficacy against and emergence of resistance in Staphylococcus aureus

被引:11
|
作者
Menday, AP
Noble, WC
机构
[1] Leo Pharmaceut Prod, Dept Med, Princes Risborough HP27 9RR, Bucks, England
[2] St Johns Inst Dermatol, London, England
关键词
bacterial resistance; betamethasone; eczema; fusidic acid; Staphylococcus aureus;
D O I
10.1080/09546630050517289
中图分类号
R75 [皮肤病学与性病学];
学科分类号
100206 ;
摘要
BACKGROUND: The bacteriological implications of treating eczema infected with Staphylococcus aureus with topical betamethasone/fusidic acid have been reviewed. METHODS: A retrospective review and analysis of results from 8 previously conducted clinical studies was performed. RESULTS: Overall, bacteriological efficacy was recorded in 326 (89.6%) of the 364 patients assessed, In comparative studies, bacteriological efficacy was 86.0% for betamethasone/neomycin (n.s.), 85.4% for betamethasone/gentamicin (n.s.), 69.6% for betamethasone/clio-quinol (P = 0.04), 70.4% for betamethasone (P < 0.01) and 25.0% for an ointment vehicle (p < 0.001), The emergence of fusidic acid-resistant strains of S. aureus was seen in nine (2.8%) patients given betamethasone/fusidic acid and in six (2.5%) patients given comparator treatment, CONCLUSION: When betamethasone/fusidic acid treatment is given for short periods there is little selection pressure on the development of resistance to fusidic acid.
引用
收藏
页码:143 / 149
页数:7
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