Fusidic acid-resistant Staphylococcus aureus (FRSA) carriage in patients with atopic eczema and pattern of prior topical fusidic acid use

被引:19
|
作者
Sule, Olajumoke
Brown, Nicholas A.
Willocks, Lorna J.
Day, Jane
Shankar, Sonal
Palmer, Christopher R.
Burrows, Nigel P.
机构
[1] Addenbrookes Hosp, Clin Microbiol & Publ Hlth Lab, Hlth Protect Agcy, Cambridge CB2 2QW, England
[2] Univ Forvie Site, Inst Publ Hlth, E England Reg Epidemiol Unit, Cambridge CB2 2SR, England
[3] Addenbrookes Hosp, Cambridge Univ Hosp NHS Fdn Trust, Dept Dermatol, Cambridge CB2 2QQ, England
[4] Univ Cambridge, Inst Publ Hlth, Dept Publ Hlth & Primary Care, Ctr Appl Med Stat, Cambridge CB2 2SR, England
关键词
eczema; Staphylococcus aureus; resistance; topical; fusidic acid;
D O I
10.1016/j.ijantimicag.2007.02.015
中图分类号
R51 [传染病];
学科分类号
100401 ;
摘要
We questioned 62 dermatology outpatients with atopic eczema and Staphylococcus aureus colonisation regarding their use of topical preparations containing fusidic acid during the previous 6 months as well as the pattern of any such use. Recent exposure to topical fusidic acid was significantly correlated with the presence of fusidic acid-resistant S. aureus (FRSA) (P = 0.04). There was also a significant trend towards increasing FRSA carriage with increased duration of use. Short courses of 2 weeks or less did not appear to change the FRSA profile compared with non-exposure, and intermittent usage appeared to be the most detrimental, although subgroup sizes were small. Our study cautions against prolonged or intermittent use of fusidic acid-containing products in patients with eczema. (c) 2007 Elsevier B.V. and the International Society of Chemotherapy. All rights reserved.
引用
收藏
页码:78 / 82
页数:5
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