Inner Ear Hair Cell Protection in Mammals against the Noise-Induced Cochlear Damage

被引：25

作者：

Waqas, Muhammad ^{[1
,2
]}

Gao, Song ^{[3
]}

Iram-us-Salam ^{[1
]}

Ali, Muhammad Kazim ^{[1
,4
]}

Ma, Yongming ^{[3
]}

Li, Wenyan ^{[5
,6
]}

机构：

[1] Fed Urdu Univ Arts Sci & Technol, Dept Biotechnol, Gulshan E Iqbal Campus, Karachi, Pakistan

[2] Southeast Univ, Inst Life Sci, Minist Educ, Key Lab Dev Genes & Human Dis, Nanjing 210096, Jiangsu, Peoples R China

[3] Peoples Hosp Jiangsu Univ, Dept Otolaryngol, Zhenjiang 212002, Peoples R China

[4] Univ Karachi, Karachi Inst Biotechnol & Genet Engn, Karachi 72570, Pakistan

[5] Fudan Univ, Eye & ENT Hosp, ENT Inst, State Key Lab Med Neurobiol, Shanghai 200031, Peoples R China

[6] Fudan Univ, Eye & ENT Hosp, Dept Otorhinolaryngol, State Key Lab Med Neurobiol, Shanghai 200031, Peoples R China

来源：

NEURAL PLASTICITY | 2018年 / 2018卷

关键词：

INDUCED HEARING-LOSS; STRESS-INDUCED APOPTOSIS; NECROSIS-FACTOR-ALPHA; OXIDATIVE STRESS; N-ACETYLCYSTEINE; ACOUSTIC TRAUMA; INCREASES SUSCEPTIBILITY; GENE POLYMORPHISMS; AUDITORY FUNCTION; IMPULSE NOISE;

D O I：

10.1155/2018/3170801

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Inner ear hair cells are mechanosensory receptors that perceive mechanical sound and help to decode the sound in order to understand spoken language. Exposure to intense noise may result in the damage to the inner ear hair cells, causing noise-induced hearing loss (NIHL). Particularly, the outer hair cells are the first and the most affected cells in NIHL. After acoustic trauma, hair cells lose their structural integrity and initiate a self-deterioration process due to the oxidative stress. The activation of different cellular death pathways leads to complete hair cell death. This review specifically presents the current understanding of the mechanism exists behind the loss of inner ear hair cell in the auditory portion after noise-induced trauma. The article also explains the recent hair cell protection strategies to prevent the damage and restore hearing function in mammals.

引用

页数：9

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