Anti-Candida activity of a new platinum derivative

被引：5
|
作者：
Watanabe, T
Takano, M
Ogasawara, A
Mikami, T
Kobayashi, T
Watabe, M
Matsumoto, T [1 ]
机构：
[1] Tohoku Pharmaceut Univ, Dept Microbiol, Sendai, Miyagi 9818558, Japan
[2] Kogakuin Univ, Gen Educ Dept, Tokyo 1920015, Japan
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2000年 / 44卷 / 10期
关键词：
D O I：
10.1128/AAC.44.10.2853-2854.2000
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
A new platinum derivative of the form H[Pt(IV) (Hdigly)Cl-2(OH)(2)] (Hdigly=glycylglycine) damaged the Candida albicans cell membrane and inhibited the growth of the cells. The cytotoxic activity of H[Pt(IV) (Hdigly)Cl-2(OH)(2)] on mammalian cells was 10-fold lower than that of cis-diammine-dichloroplatinum (cisplatin). Substitution of platinum for peptides is effective for enhancement of antifungal activity and reduction of the toxicity to mammalian cells.
引用
收藏
页码：2853 / 2854
页数：2
相关论文
共 50 条
  • [1] Anti-Candida activity of YH-1715R, a new triazole derivative
    Park, KS
    Kang, HI
    Lee, JW
    Paik, YK
    [J]. JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY, 2004, 14 (04) : 693 - 697
  • [2] ANTI-CANDIDA ACTIVITY OF AZOLES
    VANCUTSEM, J
    VANGERVEN, F
    JANSSEN, PAJ
    [J]. ANNALES DE BIOLOGIE CLINIQUE, 1987, 45 (06) : 661 - 668
  • [3] The anti-Candida activity of Shikon
    Sasaki, K
    Yoshizaki, F
    Abe, H
    [J]. YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, 2000, 120 (06): : 587 - 589
  • [4] Anti-Candida Activity of Essential Oils
    Palmeira-de-Oliveira, A.
    Salgueiro, L.
    Palmeira-de-Oliveira, R.
    Martinez-de-Oliveira, J.
    Pina-Vaz, C.
    Queiroz, J. A.
    Rodrigues, A. G.
    [J]. MINI-REVIEWS IN MEDICINAL CHEMISTRY, 2009, 9 (11) : 1292 - 1305
  • [5] Anti-Candida activity of sodium sulfite
    Ogasawara, Ayako
    Ino, Yuki
    Sato, Keio
    Nakajima, Yuta
    Bessho, Satoko
    Watanabe, Toshihiko
    Mikami, Takeshi
    Matsumoto, Tatsuji
    [J]. BIOLOGICAL & PHARMACEUTICAL BULLETIN, 2008, 31 (06) : 1101 - 1103
  • [6] Antimicrobial Peptides with Anti-Candida Activity
    Perez-Rodriguez, Aitzol
    Eraso, Elena
    Quindos, Guillermo
    Mateo, Estibaliz
    [J]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2022, 23 (16)
  • [7] Design of endoperoxides with anti-Candida activity
    Avery, Thomas D.
    Macreadie, Peter I.
    Greatrex, Ben W.
    Robinson, Tony V.
    Taylor, Dennis K.
    Macreadie, Ian G.
    [J]. BIOORGANIC & MEDICINAL CHEMISTRY, 2007, 15 (01) : 36 - 42
  • [8] In vitro and in vivo anti-Candida activity of new albaconazole derivatives
    Pagniez, F.
    Guillon, R.
    Picot, C.
    Morio, F.
    Loge, C.
    Le Pape, P.
    [J]. MYCOSES, 2011, 54 : 64 - 64
  • [9] TOYOCAMYCIN, A NEW ANTI-CANDIDA ANTIBIOTICS
    NISHIMURA, H
    KATAGIRI, K
    SATO, K
    MAYAMA, M
    SHIMAOKA, N
    [J]. JOURNAL OF ANTIBIOTICS, 1956, 9 (02): : 60 - 62
  • [10] Anti-Candida Activity of New Azole Derivatives Alone and in Combination with Fluconazole
    Shi, Ce
    Liu, Chunli
    Liu, Jinyan
    Wang, Ying
    Li, Jian
    Xiang, Mingjie
    [J]. MYCOPATHOLOGIA, 2015, 180 (3-4) : 203 - 207
12345