Function and regulation of Cullin-RING ubiquitin ligases

被引：1759
|
作者：
Petroski, MD
Deshaies, RJ
机构：
[1] CALTECH, Div Biol, Pasadena, CA 91125 USA
[2] CALTECH, Howard Hughes Med Inst, Pasadena, CA 91125 USA
来源：
NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2005年 / 6卷 / 01期
关键词：
D O I：
10.1038/nrm1547
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Cullin - RING complexes comprise the largest known class of ubiquitin ligases. Owing to the great diversity of their substrate-receptor subunits, it is possible that there are hundreds of distinct cullin - RING ubiquitin ligases in eukaryotic cells, which establishes these enzymes as key mediators of post-translational protein regulation. In this review, we focus on the composition, regulation and function of cullin - RING ligases, and describe how these enzymes can be characterized by a set of general principles.
引用
收藏
页码：9 / 20
页数：12
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