Function and regulation of Cullin-RING ubiquitin ligases

被引：1759
|
作者：
Petroski, MD
Deshaies, RJ
机构：
[1] CALTECH, Div Biol, Pasadena, CA 91125 USA
[2] CALTECH, Howard Hughes Med Inst, Pasadena, CA 91125 USA
来源：
NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2005年 / 6卷 / 01期
关键词：
D O I：
10.1038/nrm1547
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Cullin - RING complexes comprise the largest known class of ubiquitin ligases. Owing to the great diversity of their substrate-receptor subunits, it is possible that there are hundreds of distinct cullin - RING ubiquitin ligases in eukaryotic cells, which establishes these enzymes as key mediators of post-translational protein regulation. In this review, we focus on the composition, regulation and function of cullin - RING ligases, and describe how these enzymes can be characterized by a set of general principles.
引用
收藏
页码：9 / 20
页数：12
相关论文
共 50 条
  • [1] Regulation of cell cycle drivers by Cullin-RING ubiquitin ligases
    Sang-Min Jang
    Christophe E. Redon
    Bhushan L. Thakur
    Meriam K. Bahta
    Mirit I. Aladjem
    [J]. Experimental & Molecular Medicine, 2020, 52 : 1637 - 1651
  • [2] Regulation of cell cycle drivers by Cullin-RING ubiquitin ligases
    Jang, Sang-Min
    Redon, Christophe E.
    Thakur, Bhushan L.
    Bahta, Meriam K.
    Aladjem, Mirit I.
    [J]. EXPERIMENTAL AND MOLECULAR MEDICINE, 2020, 52 (10): : 1637 - 1651
  • [3] Cullin-RING ubiquitin ligases: global regulation and activation cycles
    Dimple R Bosu
    Edward T Kipreos
    [J]. Cell Division, 3
  • [4] Cullin-RING ubiquitin ligases: global regulation and activation cycles
    Bosu, Dimple R.
    Kipreos, Edward T.
    [J]. CELL DIVISION, 2008, 3 (1)
  • [5] The Cullin-RING Ubiquitin-Protein Ligases
    Hua, Zhihua
    Vierstra, Richard D.
    [J]. ANNUAL REVIEW OF PLANT BIOLOGY, VOL 62, 2011, 62 : 299 - 334
  • [6] Viral Manipulations of the Cullin-RING Ubiquitin Ligases
    Liu, Ying
    Tan, Xu
    [J]. CULLIN-RING LIGASES AND PROTEIN NEDDYLATION: BIOLOGY AND THERAPEUTICS, 2020, 1217 : 99 - 110
  • [7] Function and regulation of cullin–RING ubiquitin ligases
    Matthew D. Petroski
    Raymond J. Deshaies
    [J]. Nature Reviews Molecular Cell Biology, 2005, 6 : 9 - 20
  • [8] Cullin-RING ligases in regulation of autophagy
    Cui, Danrui
    Xiong, Xiufang
    Zhao, Yongchao
    [J]. CELL DIVISION, 2016, 11
  • [9] Cullin-RING ligases in regulation of autophagy
    Danrui Cui
    Xiufang Xiong
    Yongchao Zhao
    [J]. Cell Division, 11
  • [10] Regulation of DNA damage response pathways by the cullin-RING ubiquitin ligases
    Hannah, Jeffrey
    Zhou, Pengbo
    [J]. DNA REPAIR, 2009, 8 (04) : 536 - 543
12345