High ANKZF1 expression is associated with poor overall survival and recurrence-free survival in colon cancer

被引：22
|
作者：
Zhou, Xin [1 ]
Shang, Yan-Na [1 ]
Lu, Ran [1 ]
Fan, Chuan-Wen [1 ,2 ,3 ]
Mo, Xian-Ming [1 ]
机构：
[1] Sichuan Univ, West China Hosp, State Key Lab Biotherapy, Lab Stem Cell Biol, Chengdu 610041, Peoples R China
[2] Sichuan Univ, West China Hosp, State Key Lab Biotherapy, Inst Digest Surg, Chengdu 610041, Peoples R China
[3] Linkoping Univ, Fac Hlth Sci, Div Oncol, Dept Clin & Expt Med, Linkoping, Sweden
来源：
FUTURE ONCOLOGY | 2019年 / 15卷 / 18期
关键词：
ANKZF1; colon cancer; OS; overall survival; recurrence-free survival; RFS; WGCNA; TUMOR MICROSATELLITE-INSTABILITY; YOUNG-PATIENTS; PATHWAYS; SURVEILLANCE; BIOMARKERS; DIAGNOSIS; RAS; M2;
D O I：
10.2217/fon-2018-0920
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Aim: To investigate the association and prognostic value of ANKZF1 gene for survival in colorectal cancer, the mechanism of ANKZF1 level alteration and correlated signaling pathways ANKZF1 is involved. Patients & methods: The Cancer Genome Atlas COREAD dataset was analyzed by bioinformatical investigation. Results: High ANKZF1 expression is associated with poor overall survival (hazard ratio [HR]: 2.094; 95% CI: 1.188-3.689; p=0.011) and recurrence-free survival (HR: 1.762; 95% CI: 1.021-3.042; p=0.042) in colon cancer. Bioinformatical analysis showed ANKZF1 was upregulated by amplification and exon expression. ANKZF1 was associated with angiogenesis and cancer signaling pathways. Conclusion: High ANKZF1 is an independent factor of poor survival (overall survival and recurrence-free survival) in colon cancer by taking part in angiogenesis and some cancer signaling pathways.
引用
收藏
页码：2093 / 2106
页数：14
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