Ligusaginoids A-D, four eremophilane-type sesquiterpenoid dimers and trimers from Ligularia sagitta

被引：9

作者：

Li, Hang-Ying ^{[1
]}

Zheng, Zai-Qin ^{[1
]}

Wei, Wen-Jun ^{[1
]}

Chen, Jian-Jun ^{[1
]}

Gao, Kun ^{[1
]}

机构：

[1] Lanzhou Univ, Coll Chem & Chem Engn, State Key Lab Appl Organ Chem, Lanzhou 730000, Gansu, Peoples R China

来源：

TETRAHEDRON LETTERS | 2018年 / 59卷 / 38期

基金：

中国国家自然科学基金;

关键词：

Ligularia sagitta; Eremophilane; Sesquiterpenoid; Structure determination; Antibacterial activities; CONSTITUENTS;

D O I：

10.1016/j.tetlet.2018.08.009

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Four novel highly oxygenated eremophilane-type sesquiterpenoid dimers and trimers with the unique 6/6/5/5 polycyclic skeleton, designated as ligusaginoids A-D (1-4), were isolated from the aerial parts of Ligularia sagitta. Their structures with absolute configurations were determined by a combined method. Moreover, a plausible biosynthetic pathway of 1-4 was also proposed. These compounds showed weak antibacterial activities. (C) 2018 Elsevier Ltd. All rights reserved.

引用

页码：3461 / 3466

页数：6

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