Diagnosis of MALT Lymphoma from Surveillance Endoscopy of a Patient with a CDH1 Gene Germline Mutation

被引：1
|
作者：
Pinto, Claudia [1 ]
Cunha, Ana Luisa [2 ]
Rodrigues, Angelo [2 ]
Dias, Renata [2 ]
Brandao, Catarina [1 ]
Dinis-Ribeiro, Mario [1 ,3 ]
机构：
[1] Portuguese Oncol Inst Porto, Gastroenterol Dept, Rua Dr Antonio Bernardino Almeida 865, P-4200072 Porto, Portugal
[2] Portuguese Oncol Inst Porto, Pathol Dept, Porto, Portugal
[3] Ctr Res Hlth Technol & Informat Syst CINTESIS, Fac Med, Porto, Portugal
来源：
GE PORTUGUESE JOURNAL OF GASTROENTEROLOGY | 2022年 / 29卷 / 01期
关键词：
CDH1; protein; Stomach neoplasms; Helicobacter pylori; Marginal zone B-cell lymphoma; DIFFUSE GASTRIC-CANCER; MANAGEMENT; TISSUE;
D O I：
10.1159/000514652
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
Carriers of the mutated CDH1 gene have an increased risk of developing early-onset signet-ring cell (diffuse) gastric cancer. We present a case of a young patient with a confirmed mutation of the CDH1 gene, who was diagnosed with a gastric marginal zone B-cell lymphoma (MZL) of mucosa-associated lymphoid tissue (MALT lymphoma) from surveillance endoscopy. He underwent Helicobacter pylori eradication treatment and was subsequently submitted to a total prophylactic gastrectomy. The surgical specimen only revealed foci of signet-ring cell carcinoma (SRCC) in situ without lymphoma signs. We highlight here the occurrence of other pathology in high-risk patients as well as its possible influence on the decision to perform gastrectomy.
引用
收藏
页码：51 / 55
页数：5
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