TGF-β1 and IL-10 modulate IL-1β-induced membrane and soluble ICAM-1 in human myoblasts

被引：17
|
作者：
Marino, M [1 ]
Scuderi, F [1 ]
Mannella, F [1 ]
Bartoccioni, E [1 ]
机构：
[1] Univ Sacred Heart, Inst Gen Pathol, I-00168 Rome, Italy
来源：
JOURNAL OF NEUROIMMUNOLOGY | 2003年 / 134卷 / 1-2期
关键词：
interleukin-1 (IL-1); interleukin-10 (IL-10); transforming growth factor-beta (TGF-beta); intercellular adhesion molecule-1 (ICAM-1); human myoblast; muscle;
D O I：
10.1016/S0165-5728(02)00399-5
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
We have previously shown that interleukin (IL)-1beta and other inflammatory cytokines are able to induce the expression of membrane and soluble intercellular adhesion molecule (ICAM)-1 on human myoblasts. In this paper we found that IL-10 and transforming growth factor (TGF)-beta1 are able to prevent IL-1beta-induced membrane and soluble ICAM-I protein expression on human myoblasts, with different time courses. The effect of both cytokines is associated to a reduction in ICAM-1 mRNA. Our findings suggest that IL-10 and TGF-beta1 are able to influence the inflammatory process in muscle tissue at least in part by means of control of membrane and soluble ICAM-1. (C) 2002 Elsevier Science B.V. All rights reserved.
引用
收藏
页码：151 / 157
页数：7
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