Progestins and Carcinogenesis

被引:0
|
作者
Shchelkunova, T. A. [1 ]
Morozov, I. A. [2 ]
机构
[1] Moscow MV Lomonosov State Univ, Fac Biol, Moscow 119992, Russia
[2] Russian Acad Sci, Engelhardt Inst Mol Biol, Moscow 119991, Russia
基金
俄罗斯基础研究基金会;
关键词
progestins; estrogens; receptors; signaling pathways; paracrine regulation; proliferation; apoptosis; carcinogenesis; epithelial-mesenchymal transition; OVARIAN-CANCER CELLS; MEMBRANE PROGESTERONE-RECEPTORS; SEX STEROID-RECEPTORS; HUMAN-BREAST-CANCER; ENDOMETRIAL ADENOCARCINOMA CELLS; SURFACE EPITHELIAL-CELLS; UTERINE LEIOMYOMA CELLS; EPIDERMAL-GROWTH-FACTOR; CENTRAL-NERVOUS-SYSTEM; GENE-EXPRESSION;
D O I
10.1134/S0026893316010179
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Progesterone and its analogs may exert opposite effects on cell proliferation, apoptosis, and epithelial-mesenchymal transition, leading to higher cell motility and metastasis. Their ultimate effect is determined by a number of factors: the structure and concentration of the steroid, its affinity for various forms of steroid hormone receptors, activation of nongenomic mechanisms, the composition and proportion of different progesterone receptors and sensors, activity of various signaling pathways, the set of transcription factor coregulators, DNA accessibility in chromatin, activity of steroid-metabolizing enzymes, intercellular interactions within tissues, the hormonal status of the body, disease stage, and species-specific features. The review considers the factors that determine the role progestins play in proliferation and apoptosis of human tumor cells of various origins.
引用
收藏
页码:7 / 21
页数:15
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