Prostate Cancer Stem Cells: Clinical Aspects and Targeted Therapies

被引：20
|
作者：
Wolf, Isis [1 ,2 ]
Gratzke, Christian [1 ,2 ]
Wolf, Philipp [1 ,2 ]
机构：
[1] Univ Freiburg, Med Ctr, Dept Urol, Freiburg, Germany
[2] Univ Freiburg, Fac Med, Freiburg, Germany
来源：
FRONTIERS IN ONCOLOGY | 2022年 / 12卷
关键词：
prostate cancer; prostate cancer stem cells; prostate cancer stem cell hypothesis; prostate cancer stem cell antigens; prostate cancer stem cell therapy; RADICAL PROSTATECTOMY; ANDROGEN DEPRIVATION; LUMINAL CELLS; IN-VITRO; EXPRESSION; MARKER; METASTASIS; RECURRENCE; RESISTANCE; CARCINOMA;
D O I：
10.3389/fonc.2022.935715
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Despite decades of research and successful improvements in diagnosis and therapy, prostate cancer (PC) remains a major challenge. In recent years, it has become clear that PC stem cells (PCSCs) are the driving force in tumorigenesis, relapse, metastasis, and therapeutic resistance of PC. In this minireview, we discuss the impact of PCSCs in the clinical practice. Moreover, new therapeutic approaches to combat PCSCs are presented with the aim to achieve an improved outcome for patients with PC.
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页数：9
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