Clarithromycin resistance stability in Helicobacter pylori:: influence of the MIC and type of mutation in the 23S rRNA

被引：24

作者：

Alarcón, T ^{[1
]}

Domingo, D ^{[1
]}

Prieto, N ^{[1
]}

López-Brea, M ^{[1
]}

机构：

[1] Univ Madrid, Hosp Princesa, Dept Microbiol, Madrid 28006, Spain

来源：

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY | 2000年 / 46卷 / 04期

关键词：

D O I：

10.1093/jac/46.4.613

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Thirty clarithromycin-resistant Helicobacter pylori strains (MIC range 8-64 mg/L) were subcultured in a drug-free medium and the MIC was determined every five passages to detect in vitro stability of resistance. Three out of the 30 (10%) lost their resistance after 10, 13 or 18 subcultures (MIC decrease from 8 to 0.008, from 16 to 0.064 and from 32 to 0.016 mg/L). The effect of four macrolides at subinhibitory concentrations on the development of resistance was studied in H. pylori NCTC 11638 and TIGR 26695. A change in the MIC was observed only when NCTC11638 was exposed to 0.5 x MIC of erythromycin for 20 days.

引用

页码：613 / 616

页数：4

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