A convenient method for the synthesis of phosphatidylcholines

被引：0
|
作者：
Bragina, NA [1 ]
Kurochkina, EY [1 ]
Anikin, AV [1 ]
Chupin, VV [1 ]
机构：
[1] Lomonosov Acad Fine Chem Technol, Moscow 117571, Russia
来源：
BIOORGANICHESKAYA KHIMIYA | 1998年 / 24卷 / 02期
关键词：
deuterium-labeled lipids; phosphatidylcholine; phosphorylation; choline tetraphenylborate;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
A convenient method for the preparation of phosphatidylcholines is proposed, which is based upon phosphorylation of diglycerides with phosphorus oxychloride followed by a reaction of the resulting dichlorophosphates with choline tetraphenylborates. This requires no isolation of intermediates and affords phosphatidylcholines with >60% yields. By its use, two novel ester and ether phosphatidylcholines with deuterium labels in the hydrophilic moiety, rac-1,2-dihexadecylglycero-3-phospho(H-2(13))choline and rac-1,2-dipalmitoylglycero-3-phospho(H-2(13))choline, were synthesized.
引用
收藏
页码：147 / 150
页数：4
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