The birth of a deadly yeast: tracing the evolutionary emergence of virulence traits in Candida glabrata

被引：0

作者：

Gabaldon, Toni ^{[1
,2
,3
]}

Carrete, Laia ^{[1
,2
]}

机构：

[1] Barcelona Inst Sci & Technol, Bioinformat & Genom Programme, Ctr Genom Regulat CRG, Dr Aiguader 88, Barcelona 08003, Spain

[2] Univ Pompeu Fabra, Barcelona 08003, Spain

[3] Inst Catalana Recerca & Estudis Avancats, Pg Lluis Companys 23, Barcelona 08010, Spain

来源：

FEMS YEAST RESEARCH | 2016年 / 16卷 / 02期

基金：

欧盟地平线“2020”;

关键词：

Candida glabrata; virulence; evolution; Nakaseomyces; Candida; SACCHAROMYCES; BRACARENSIS; PATHOGENS; GENOME; IDENTIFICATION; PHYLOGENY; ADHESINS; SEQUENCE; ALBICANS; HEALTH;

D O I：

10.1093/femsyr/fov110

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The yeast Candida glabrata is an opportunistic human fungal pathogen whose incidence has increased in the last two decades. Despite its name, this yeast is only distantly related to the model fungal pathogen C. albicans, and more closely related to Saccharomyces cerevisiae and other yeasts that underwent an ancient whole-genome duplication. Understanding what specific traits make C. glabrata a successful opportunistic pathogen within a clade of mostly innocuous yeasts, and how these compare to virulence traits in distant pathogens such as C. albicans is a focus of intense research. From an evolutionary perspective, uncovering how the ability to infect humans has emerged multiple, independent times in different lineages may reveal new disease mechanisms and provide us with the capacity to predict which genomic features in a clade may confer a higher potential to develop virulence against humans.

引用

页数：9