PRMT5 is a Poor Prognostic Marker for NSCLC and Inhibition of PRMT5 Results in Increased Lung Cancer Sensitivity to Cisplatin and Radiotherapy

被引:0
|
作者
Welliver, Meng [1 ]
Jin, Feng [2 ]
Otterson, Gregory [1 ]
Carbone, David [3 ]
机构
[1] Ohio State Univ Ccc, Radiat Oncol, Columbus, OH USA
[2] Ohio State Univ, Radiat Oncol, Columbus, OH 43210 USA
[3] Ohio State Univ Ccc, Internal Med, Columbus, OH USA
关键词
D O I
10.1016/j.jtho.2016.11.1144
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
P2.01-092
引用
收藏
页码:S844 / S844
页数:1
相关论文
共 50 条
  • [31] PRMT5 INHIBITION SENSITIZES GLIOBLASTOMA MODELS TO TRAMETINIB TREATMENT
    Otani, Yoshihiro
    Namagiri, Sriya
    Thammegowda, Shilpa
    Sur, Hannah
    Chowdhury, Ashis
    Lewis, Cole
    Shimizu, Toshihiko
    Lee, Tae Jin
    Maric, Dragan
    Yoo, Ji Young
    Heiss, John
    Kaur, Balveen
    Banasavadi-Siddegowda, Yeshavanth Kumar
    NEURO-ONCOLOGY, 2020, 22 : 31 - 31
  • [32] Protein Arginine Methyltransferase 5 (PRMT5) and the ERK1/2 & PI3K Pathways: A Case for PRMT5 Inhibition and Combination Therapies in Cancer
    Sapir, Tzuriel
    Shifteh, David
    Pahmer, Moshe
    Goel, Sanjay
    Maitra, Radhashree
    MOLECULAR CANCER RESEARCH, 2021, 19 (03) : 388 - 394
  • [33] CHARACTERIZATION OF SPLICING ABERRATIONS INDUCED BY PRMT5 INHIBITION IN GLIOBLASTOMA
    Huo, Longfei
    Sharma, Pratibha
    Tsai, Tsung-Lin
    Chen, Xiaohua
    Yu, Chunlei
    Xu, Jihong
    Ju, Zhenlin
    Li, Ziyi
    Scherle, Peggy
    Vaddi, Kris
    Baiocchi, Robert A.
    Sampath, Deepa
    Shukla, Sachet
    Puduvalli, Vinay K.
    NEURO-ONCOLOGY, 2024, 26
  • [34] PRMT5 promotes chemotherapy-induced neuroendocrine differentiation in NSCLC
    Shen, Qi
    Liu, Yi
    Deng, Xuehong
    Hu, Chang-Deng
    THORACIC CANCER, 2023, 14 (18) : 1764 - 1773
  • [35] Protein Arginine Methyltransferase 5 (PRMT5) Mutations in Cancer Cells
    Rasheed, Shayaan
    Bouley, Renee A.
    Yoder, Ryan J.
    Petreaca, Ruben C.
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2023, 24 (07)
  • [36] A comprehensive investigation of PRMT5 in the prognosis and ion channel features of lung cancer
    Wang, Yan
    Chu, Daifang
    Li, Haichao
    Fan, Jiangjiang
    Zhu, Ximing
    Ma, Yulong
    Gu, Zhongping
    Xie, Nianlin
    Jing, Pengyu
    FRONTIERS IN ONCOLOGY, 2024, 14
  • [37] Establishing the role of PRMT5 in lung cancer tumorigenicity and modulation of expression in smokers
    Ali, Syed N.
    Patel, Meet
    Dieng, Bamby
    Lund, Cody
    Puri, Neelu
    CANCER RESEARCH, 2024, 84 (06)
  • [38] Medicinal chemistry strategies targeting PRMT5 for cancer therapy
    Fu, Siyu
    Zheng, Qinwen
    Zhang, Dan
    Lin, Congcong
    Ouyang, Liang
    Zhang, Jifa
    Chen, Lei
    EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2022, 244
  • [39] PRMT5: a putative oncogene and therapeutic target in prostate cancer
    Beketova, Elena
    Owens, Jake L.
    Asberry, Andrew M.
    Hu, Chang-Deng
    CANCER GENE THERAPY, 2022, 29 (3-4) : 264 - 276
  • [40] PRMT5: a putative oncogene and therapeutic target in prostate cancer
    Elena Beketova
    Jake L. Owens
    Andrew M. Asberry
    Chang-Deng Hu
    Cancer Gene Therapy, 2022, 29 : 264 - 276