Generation of induced pluripotent stem cell line (ZZUi0021-A) from a patient with spinocerebellar ataxia type 19

被引：1
|
作者：
Liu, Fen [1 ]
Fan, Yu [1 ]
Fan, Liyuan [1 ]
Li, Mengjie [1 ]
Zhang, Qimeng [1 ]
Mao, Chengyuan [1 ]
Wu, Jun [1 ]
Zhang, Shuo [1 ]
Hu, Zhengwei [1 ]
Shi, Changhe [1 ]
Xu, Yuming [1 ]
机构：
[1] Zhengzhou Univ, Affiliated Hosp 1, Dept Neurol, Zhengzhou 450052, Peoples R China
来源：
STEM CELL RESEARCH | 2021年 / 53卷
基金：
中国国家自然科学基金;
关键词：
D O I：
10.1016/j.scr.2021.102320
中图分类号：
Q813 [细胞工程];
学科分类号：
摘要：
Spinocerebellar ataxia type 19 (SCA19) is an extremely rare autosomal dominant cerebellar ataxia hereditary that caused by the KCND3 gene mutation. And has a complex pathogenesis. At present, its pathogenesis is still unclear, and there is no effective treatment for SCA19. So, to study its pathogenesis and find effective treatments, we collected the fifibroblasts from a patient with SCA19, then successfully transformed the fifibroblasts into induced pluripotent stem cells (iPSCs) and construct a SCA19 pathological cell mode. This study provides a basis for elucidating its pathogenesis and providing new treatment options.
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页数：4
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