Rhodium-catalyzed conjugate addition-enantioselective protonation:: The synthesis of α,α'-dibenzyl esters

被引：46

作者：

Frost, Christopher G. ^{[1
]}

Penrose, Stephen D.

Lambshead, Kim

Raithby, Paul R.

Warren, John E.

GleaveO, Robert

机构：

[1] Univ Bath, Dept Chem, Bath BA2 7AY, Avon, England

[2] GlaxoSmithKline Inc, Neurol & Gastrointestinal Ctr Excellence Drug Dis, Harlow CM19 5AW, Essex, England

[3] CCLRC, Daresbury Lab, Warrington WA4 4AD, Cheshire, England

来源：

ORGANIC LETTERS | 2007年 / 9卷 / 11期

关键词：

D O I：

10.1021/ol070603g

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

alpha-Benzyl acrylates, which are conveniently prepared from the corresponding aldehydes, can be employed as substrates in a tandem rhodium-catalyzed conjugate addition-enantioselective protonation protocol to afford enantiomerically enriched alpha, alpha'-dibenzyl esters. The synergistic effect of enantiopure ligand and proton source was rapidly optimized with use of a microwave reactor.

引用

页码：2119 / 2122

页数：4

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