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Retinal cholinergic and dopaminergic deficits of aged rats are improved following treatment with GM1 ganglioside
被引:4
|作者:
Goettl, VM
Wemlinger, TA
Fong, TG
Neff, NH
Hadjiconstantinou, M
[1
]
机构:
[1] Ohio State Univ, Coll Med & Publ Hlth, Dept Pharmacol, Columbus, OH 43210 USA
[2] Ohio State Univ, Coll Med & Publ Hlth, Dept Psychiat, Columbus, OH 43210 USA
关键词:
retina;
aging;
dopamine;
tyrosine hydroxylase;
mazindol binding;
choline acetyltransferase;
hemicholinium-3;
binding;
GM1;
ganglioside;
D O I:
10.1016/S0006-8993(00)02598-1
中图分类号:
Q189 [神经科学];
学科分类号:
071006 ;
摘要:
Selected cholinergic and dopaminergic markers were compared in the retina of aged (20-22-months-old) and young (3-months-old) rats before and after treatment with GM1 ganglioside. The dopaminergic markers, tyrosine hydroxylase, aromatic L-amino acid decarboxylase, dopamine, 3,4-dihydroxyphenylacetic acid and homovanillic acid were comparable in the young and aged animals and GM1 treatment did not alter them. In contrast, mazindol binding, a marker fur the dopamine transporter, was diminished in the aged retina and treatment with GM1 restored binding to values found in the young animals. The cholinergic markers choline acetyltransferase and hemicholinium-3 binding, a marker for the high-affinity choline transport, were depressed in aged rats and GM1 corrected the deficits. (C) 2000 Elsevier Science B.V. All rights reserved.
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页码:1 / 6
页数:6
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