A Simple Copper-Catalyzed Cascade Synthesis of 2-Amino-1H-indole-3-carboxylate Derivatives

被引：54

作者：

Yang, Xiaobo ^{[1
,2
]}

Fu, Hua ^{[1
]}

Qiao, Renzhong ^{[2
]}

Jiang, Yuyang ^{[1
,3
]}

Zhao, Yufen ^{[1
]}

机构：

[1] Tsinghua Univ, Dept Chem, Minist Educ, Key Lab Bioorgan Phosphorus Chem & Chem Biol, Beijing 100084, Peoples R China

[2] Beijing Univ Chem Technol, Coll Life Sci & Technol, State Key Lab Chem Resource Engn, Dept Pharmaceut Engn, Beijing 100029, Peoples R China

[3] Tsinghua Univ, Grad Sch Shenzhen, Key Lab Chem Biol Guangdong Prov, Shenzhen 518057, Peoples R China

来源：

ADVANCED SYNTHESIS & CATALYSIS | 2010年 / 352卷 / 06期

基金：

中国国家自然科学基金;

关键词：

2-amino-1H-indole-3-carboxylates; cascade reactions; copper; nitrogen heterocycles; synthetic methods; HIGHLY FUNCTIONALIZED INDOLES; ONE-POT SYNTHESIS; C-O; EFFICIENT SYNTHESIS; COUPLING REACTIONS; AMIDINE HYDROCHLORIDES; NITROGEN-HETEROCYCLES; ORTHO-SUBSTITUENT; ROOM-TEMPERATURE; ARYL HALIDES;

D O I：

10.1002/adsc.200900887

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

We have developed a simple and efficient copper-catalyzed method for the synthesis of 2-amino-1H-indole-3-carboxylate derivatives via cascade reactions of substituted N-(2-halophenyl)-2,2,2-trifluoroacetamide with alkyl 2-cyanoacetate or malononitrile under mild conditions, and the method is of wide practical application.

引用

页码：1033 / 1038

页数：6

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