A Simple Copper-Catalyzed Cascade Synthesis of 2-Amino-1H-indole-3-carboxylate Derivatives

被引：54
|
作者：
Yang, Xiaobo [1 ,2 ]
Fu, Hua [1 ]
Qiao, Renzhong [2 ]
Jiang, Yuyang [1 ,3 ]
Zhao, Yufen [1 ]
机构：
[1] Tsinghua Univ, Dept Chem, Minist Educ, Key Lab Bioorgan Phosphorus Chem & Chem Biol, Beijing 100084, Peoples R China
[2] Beijing Univ Chem Technol, Coll Life Sci & Technol, State Key Lab Chem Resource Engn, Dept Pharmaceut Engn, Beijing 100029, Peoples R China
[3] Tsinghua Univ, Grad Sch Shenzhen, Key Lab Chem Biol Guangdong Prov, Shenzhen 518057, Peoples R China
来源：
ADVANCED SYNTHESIS & CATALYSIS | 2010年 / 352卷 / 06期
基金：
中国国家自然科学基金;
关键词：
2-amino-1H-indole-3-carboxylates; cascade reactions; copper; nitrogen heterocycles; synthetic methods; HIGHLY FUNCTIONALIZED INDOLES; ONE-POT SYNTHESIS; C-O; EFFICIENT SYNTHESIS; COUPLING REACTIONS; AMIDINE HYDROCHLORIDES; NITROGEN-HETEROCYCLES; ORTHO-SUBSTITUENT; ROOM-TEMPERATURE; ARYL HALIDES;
D O I：
10.1002/adsc.200900887
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
We have developed a simple and efficient copper-catalyzed method for the synthesis of 2-amino-1H-indole-3-carboxylate derivatives via cascade reactions of substituted N-(2-halophenyl)-2,2,2-trifluoroacetamide with alkyl 2-cyanoacetate or malononitrile under mild conditions, and the method is of wide practical application.
引用
收藏
页码：1033 / 1038
页数：6
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