Synthesis of ursolic phosphonate derivatives as potential Anti-HIV agents

被引：27

作者：

Deng, Sheng-Lou

Baglin, Isabelle

Nour, Mohammed

Flekhter, Oxana

Vita, Claudio

Cave, Christian

机构：

[1] Fac Pharm Chatenay Malabry, UMR CNRS BioCis 8076, F-92296 Chatenay Malabry, France

[2] UFR Pharm, Unite Mol Interet Biol, Dijon, France

[3] Russian Acad Sci, Ufa Sci Ctr, Inst Organ Chem, Ufa 450001, Russia

[4] Ctr Etud Atom, Dept Prot Engn & Res, Saclay, France

来源：

PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS | 2007年 / 182卷 / 05期

关键词：

alpha-aminophosphonate; anti-HIV activity; conjugate; cytotaxicity; Ursolic acid;

D O I：

10.1080/10426500601088838

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

In order to search for new anti-tumor and anti-viral agents, a series of alpha-aminophosphonate conjugates of 3-O-beta-acetyl ursolic acid were prepared. Their biological activities as cytotoxic and anti-HIV agents were evaluated. The preliminary bioassays indicate that synthesized compounds 7a-j have anti-HIV activity (targeting HIV-1 gp120 and CD4) and no cytotoxicity on HT-29 cells (human colon adenocarcinoma cell line).

引用

页码：951 / 967

页数：17

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