Synthesis of ursolic phosphonate derivatives as potential Anti-HIV agents

被引：27
|
作者：
Deng, Sheng-Lou
Baglin, Isabelle
Nour, Mohammed
Flekhter, Oxana
Vita, Claudio
Cave, Christian
机构：
[1] Fac Pharm Chatenay Malabry, UMR CNRS BioCis 8076, F-92296 Chatenay Malabry, France
[2] UFR Pharm, Unite Mol Interet Biol, Dijon, France
[3] Russian Acad Sci, Ufa Sci Ctr, Inst Organ Chem, Ufa 450001, Russia
[4] Ctr Etud Atom, Dept Prot Engn & Res, Saclay, France
来源：
PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS | 2007年 / 182卷 / 05期
关键词：
alpha-aminophosphonate; anti-HIV activity; conjugate; cytotaxicity; Ursolic acid;
D O I：
10.1080/10426500601088838
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
In order to search for new anti-tumor and anti-viral agents, a series of alpha-aminophosphonate conjugates of 3-O-beta-acetyl ursolic acid were prepared. Their biological activities as cytotoxic and anti-HIV agents were evaluated. The preliminary bioassays indicate that synthesized compounds 7a-j have anti-HIV activity (targeting HIV-1 gp120 and CD4) and no cytotoxicity on HT-29 cells (human colon adenocarcinoma cell line).
引用
收藏
页码：951 / 967
页数：17
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