New anti-malarial phenylpropanoid conjugated iridoids from Morinda morindoides

被引：23
|
作者：
Tamura, Satoru [1 ,4 ]
Kubata, Bruno Kilunga [2 ,4 ]
Syamsurizal [1 ,4 ]
Itagaki, Sawako [3 ,4 ]
Horii, Toshihiro [3 ,4 ]
Taba, Muzele Kalulu [3 ,4 ]
Murakami, Nobutoshi [1 ,4 ]
机构：
[1] Osaka Univ, Grad Sch Pharmaceut Sci, Suita, Osaka 5650871, Japan
[2] Univ Kinshasa, Dept Biol & Environm Management, Kinshasa XI, DEM REP CONGO
[3] Osaka Univ, Microbial Dis Res Inst, Suita, Osaka 5650871, Japan
[4] Univ Kinshasa, Fac Sci, Kinshasa XI, DEM REP CONGO
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2010年 / 20卷 / 05期
关键词：
Anti-malarial; Iridoid; Morinda morindoides; African medicinal plant; METABOLITES; ENZYME;
D O I：
10.1016/j.bmcl.2010.01.095
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A new phenylpropanoid conjugated iridoid together with four known congeners was isolated from Morinda morindoides, used for the therapy of malaria traditionally in some African countries, as anti-malarial principles through bioassay-guided separation. Furthermore, their absolute stereostructures were unambiguously established by a combination of modified Mosher's method and chemical correlation. (C) 2010 Elsevier Ltd. All rights reserved.
引用
收藏
页码：1520 / 1523
页数：4
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