New anti-malarial phenylpropanoid conjugated iridoids from Morinda morindoides

被引：23

作者：

Tamura, Satoru ^{[1
,4
]}

Kubata, Bruno Kilunga ^{[2
,4
]}

Syamsurizal ^{[1
,4
]}

Itagaki, Sawako ^{[3
,4
]}

Horii, Toshihiro ^{[3
,4
]}

Taba, Muzele Kalulu ^{[3
,4
]}

Murakami, Nobutoshi ^{[1
,4
]}

机构：

[1] Osaka Univ, Grad Sch Pharmaceut Sci, Suita, Osaka 5650871, Japan

[2] Univ Kinshasa, Dept Biol & Environm Management, Kinshasa XI, DEM REP CONGO

[3] Osaka Univ, Microbial Dis Res Inst, Suita, Osaka 5650871, Japan

[4] Univ Kinshasa, Fac Sci, Kinshasa XI, DEM REP CONGO

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2010年 / 20卷 / 05期

关键词：

Anti-malarial; Iridoid; Morinda morindoides; African medicinal plant; METABOLITES; ENZYME;

D O I：

10.1016/j.bmcl.2010.01.095

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A new phenylpropanoid conjugated iridoid together with four known congeners was isolated from Morinda morindoides, used for the therapy of malaria traditionally in some African countries, as anti-malarial principles through bioassay-guided separation. Furthermore, their absolute stereostructures were unambiguously established by a combination of modified Mosher's method and chemical correlation. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：1520 / 1523

页数：4

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