Bleeding Disorders in Primary Fibrinolysis

被引：6
|
作者：
Franchini, Massimo [1 ]
Zaffanello, Marco [2 ]
Mannucci, Pier Mannuccio [3 ,4 ]
机构：
[1] Carlo Poma Hosp, Dept Transfus Med & Hematol, I-46100 Mantua, Italy
[2] Univ Verona, Dept Surg Sci Dent Gynecol & Pediat, I-37126 Verona, Italy
[3] Fdn IRCCS Ca Granda Osped Maggiore Policlin, Angelo Bianchi Bonomi Hemophilia & Thrombosis Ctr, I-20122 Milan, Italy
[4] Univ Milan, I-20122 Milan, Italy
来源：
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2021年 / 22卷 / 13期
关键词：
primary hyperfibrinolysis; bleeding; hemorrhage; inherited; acquired; ACUTE PROMYELOCYTIC LEUKEMIA; QUEBEC PLATELET DISORDER; ACTIVATOR INHIBITOR TYPE-1; EPSILON-AMINOCAPROIC ACID; TRANEXAMIC ACID; ALPHA-2-PLASMIN INHIBITOR; POSTPARTUM HEMORRHAGE; PLASMINOGEN ACTIVATORS; CONGENITAL DEFICIENCY; INHERITED DEFICIENCY;
D O I：
10.3390/ijms22137027
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Fibrinolysis is a complex enzymatic process aimed at dissolving blood clots to prevent vascular occlusions. The fibrinolytic system is composed of a number of cofactors that, by regulating fibrin degradation, maintain the hemostatic balance. A dysregulation of fibrinolysis is associated with various pathological processes that result, depending on the type of abnormality, in prothrombotic or hemorrhagic states. This narrative review is focused on the congenital and acquired disorders of primary fibrinolysis in both adults and children characterized by a hyperfibrinolytic state with a bleeding phenotype.
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页数：11
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