Intron 4 polymorphism of the endothelial nitric oxide synthase gene is associated with elevated blood pressure in type 2 diabetic patients with coronary heart disease

被引:61
|
作者
Pulkkinen, A [1 ]
Viitanen, L [1 ]
Kareinen, A [1 ]
Lehto, S [1 ]
Vauhkonen, I [1 ]
Laakso, M [1 ]
机构
[1] Univ Kuopio, Dept Med, Kuopio 70210, Finland
来源
JOURNAL OF MOLECULAR MEDICINE-JMM | 2000年 / 78卷 / 07期
关键词
endothelial nitric oxide synthase gene; polymorphism; coronary heart disease; hypertension; type; 2; diabetes;
D O I
10.1007/s001090000124
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
The endothelial nitric oxide synthase (eNOS) gene is responsible for constitutive nitric oxide synthesis and arterial vasodilatation. Recently two polymorphisms, the 27-bp repeat sequence in intron 4 and the Glu298Asp substitution in exon 7 of the eNOS gene have been reported to be related to coronary heart disease (CHD). We screened these polymorphisms of the eNOS gene in 308 unrelated nondiabetic subjects with CHD, in 251 unrelated patients with type 2 diabetes with CHD, and in 110 randomly selected healthy subjects without CHD. The 4a and Asp298 allele frequencies of the eNOS gene were 0.19 and 0.36 in nondiabetic patients with CHD, 0.21 and 0.27 in type 2 diabetic patients with CHD, and 0.16 and 0.31 in nondiabetic subjects without CHD (n.s. between the groups). The Asp298 allele in exon 7 of the eNOS gene was not associated with elevated blood pressure in any of the study groups. Among type 2 diabetic patients with CHD the 4a allele in intron 4 of the eNOS gene was associated with elevated levels of systolic (P=0.035) and mean arterial blood pressure (P=0.040). In nondiabetic subjects these associations were not statistically significant. When all study groups were pooled in statistical analysis the 4a allele of the eNOS gene was associated with elevated diastolic (P=0.032) and mean (P=0.030) arterial blood pressure even after adjustment for confounding factors. We conclude that the 4a allele of the eNOS gene is not associated with CHD or type 2 diabetes, but that it is related to elevated blood pressure levels particularly among type 2 diabetic patients with CHD.
引用
收藏
页码:372 / 379
页数:8
相关论文
共 50 条
  • [21] Endothelial constitutional nitric oxide synthase gene polymorphism is associated with coronary vasospasm
    He, Y
    Yasutake, M
    Tomita, Y
    Kusama, Y
    Takayama, M
    Munakata, K
    Takano, T
    JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2001, 37 (02) : 363A - 363A
  • [22] Association of endothelial nitric oxide synthase gene intron 4 polymorphism with end-stage renal disease
    Bellini, Maria H.
    Figueira, Marcia N.
    Piccoli, Michelly F.
    Marumo, Julio T.
    Cendoroglo, Maysa S.
    Neto, Miguel C.
    Dalboni, Maria A.
    Batista, Marcelo C.
    Goes, Miguel A.
    Schor, Nestor
    NEPHROLOGY, 2007, 12 (03) : 289 - 293
  • [23] A polymorphism in the gene for the endothelial nitric oxide synthase and diabetic nephropathy
    Degen, B
    Schmidt, S
    Ritz, E
    NEPHROLOGY DIALYSIS TRANSPLANTATION, 2001, 16 (01) : 185 - 185
  • [24] A promoter polymorphism of the endothelial nitric oxide synthase gene reduces endothelial nitric oxide synthase expression in patients with heart failure
    Doshi, Amit A.
    Lesinski, Amanda K.
    Binkley, Philip F.
    CIRCULATION, 2006, 114 (18) : 802 - 802
  • [25] Endothelial nitric oxide synthase gene intron 4 a/b VNTR polymorphism in children with APSGN
    Hasan Dursun
    Aytul Noyan
    Selcuk Matyar
    Mithat Buyukcelik
    Mustafa Soran
    Nurcan Cengiz
    Gulsah Seydaoglu
    Gulen Attila
    Aysun K. Bayazit
    Ali Anarat
    Pediatric Nephrology, 2006, 21 : 1661 - 1665
  • [26] Endothelial nitric oxide synthase gene intron 4 a/b VNTR polymorphism in children with APSGN
    Dursun, Hasan
    Noyan, Aytul
    Matyar, Selcuk
    Buyukcelik, Mithat
    Soran, Mustafa
    Cengiz, Nurcan
    Seydaoglu, Gulsah
    Attila, Gulen
    Bayazit, Aysun K.
    Anarat, Ali
    PEDIATRIC NEPHROLOGY, 2006, 21 (11) : 1661 - 1665
  • [27] Endothelial nitric oxide synthase intron 4a/b polymorphism in coronary artery disease in Thrace region of Turkey
    Sivri, N.
    Unlu, A.
    Palabiyik, O.
    Budak, M.
    Kacmaz, Y.
    Yalta, K.
    Sipahi, T.
    BIOTECHNOLOGY & BIOTECHNOLOGICAL EQUIPMENT, 2014, 28 (06) : 1115 - 1120
  • [28] Endothelial nitric oxide synthase 4A/B gene polymorphism, coronary artery disease, and myocardial infarction in type 2 diabetes
    Pfohl, M
    Koch, M
    Karsch, KR
    Haering, HU
    Schatz, H
    DIABETES, 1999, 48 : A411 - A412
  • [29] Endothelial nitric oxide synthase gene polymorphism is associated with sickle cell disease patients in India
    Nishank, Sudhansu Sekhar
    Singh, Mendi Prema Shyam Sunder
    Yadav, Rajiv
    Gupta, Rasik Bihari
    Gadge, Vijay Sadashiv
    Gwal, Anil
    JOURNAL OF HUMAN GENETICS, 2013, 58 (12) : 775 - 779
  • [30] Endothelial nitric oxide synthase gene polymorphism is associated with sickle cell disease patients in India
    Sudhansu Sekhar Nishank
    Mendi Prema Shyam Sunder Singh
    Rajiv Yadav
    Rasik Bihari Gupta
    Vijay Sadashiv Gadge
    Anil Gwal
    Journal of Human Genetics, 2013, 58 : 775 - 779