Nitrobenzoxadiazole derivatives as nitric oxide donors: ESR study using spin trapping

被引：3

作者：

Serezhenkov, V. A. ^{[1
]}

Tkachev, N. A. ^{[1
]}

Semenyuk, Yu. P. ^{[2
]}

Kurbatov, S. V. ^{[2
]}

Kharchenko, E. Yu. ^{[2
]}

Chistyakov, V. A. ^{[2
]}

机构：

[1] Russian Acad Sci, NN Semenov Inst Chem Phys, 4 Ul Kosygina, Moscow 109991, Russia

[2] Southern Fed Univ, 194-1 Prosp Stachki, Rostov Na Donu 344090, Russia

来源：

RUSSIAN CHEMICAL BULLETIN | 2017年 / 66卷 / 01期

基金：

俄罗斯科学基金会;

关键词：

dinitrobenzofuroxans; nitric oxide; dinitrosyl iron complexes; iron-sulfur clusters; NO donor; ESR spectroscopy; biosensors; DINITROSYL-IRON COMPLEXES; SOLUBLE GUANYLATE-CYCLASE; THIOL-CONTAINING LIGANDS; NO-DONORS; FUROXANS; BENZOFUROXANS; CHEMISTRY; MECHANISM;

D O I：

10.1007/s11172-017-1702-2

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The ability of nitrobenzoxadiazoles to induce the SOX-operon from a genetically engineered biosensor based on E. coli MG 1655 (pSoxS-lux) was confirmed by the fact of producing nitric oxide. The NO-donating properties of three nitrobenzoxadiazole derivatives bearing pi-excessive carbo- and heterocycles were found by the ESR method using spin trapping. The yield of nitrogen(II) oxide was 17, 0.3, and 1.6%. Sodium sulfide accelerates the thiol-dependent transformation and increases the yield of nitric oxide to 27, 16, and 12%, respectively.

引用

页码：76 / 82

页数：7

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