Modified Method for Detection of Benzoylecgonine in Human Urine by GC-MS: Derivatization Using Pentafluoropropanol/Acetic Anhydride

被引：1
|
作者：
Serafin, Michelle C. [1 ]
Paulemon, Kasandra M. [1 ]
Fuller, Zachary J. [1 ]
Bronner, William E. [1 ]
机构：
[1] United States Army Forens Toxicol, Drug Testing Lab, Ft George G Meade, MD 20755 USA
来源：
JOURNAL OF ANALYTICAL TOXICOLOGY | 2017年 / 41卷 / 04期
关键词：
D O I：
10.1093/jat/bkx007
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
An existing GC-MS method for detecting benzoylecgonine (BZE) in urine was modified by changing derivatizing reagents. This method modification presents a cost-effective alternative derivatization procedure for the detection of BZE in urine by GC-MS. The combination of pentafluoropropanol and acetic anhydride was found to produce the same reaction product for BZE as pentafluoropropanol with pentafluoropropionic anhydride, while reducing reagent cost. With no anhydride present, derivatization of BZE by pentafluoropropanol did not occur.
引用
收藏
页码：340 / 341
页数：2
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